What we do

Naturally occurring viruses are live replication-proficient viruses specifically infecting human cancer cells while sparing their normal counterparts.

 

Since the discovery of naturally oncotropic viruses in the 1920s, various replicating viruses have shown degrees of safety and efficacy in pre-clinical and clinical application for human anti-cancer therapeutics. Cellular oncogenes such as Ras and c-Myc are known to be important host genes for oncolytic viral tropism decision.

 

Importantly, we recently discovered that cellular tumor suppressor genes are also important in determining oncolytic viral tropism. Carcinogenesis is a multi-step process involving accumulation of not only oncogene abnormality but also the accumulation of tumor suppressor gene abnormality. Thus, it is interesting that oncolytic viruses are known to exploit abnormal oncogene and cellular tumor suppressor signaling, frequently dysregulated in various human malignancies, for their decision of oncolytic specificity and efficacy.

 

Unlike oncogenes, many tumor suppressor genes such as p53, ATM, and RB are known to play important roles in genomic fidelity & maintenance. Thus tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to accumulation of genetic defects resulting in natural viral oncotropism.

 

ViroCure finds naturally occurring oncotropic viruses for targeting various human or animal malignancies, to develop safe and effective treatments to a wide variety of illnesses.

Highlights

June 2022

Cancer surgeon Prof. Dong-guk Park appointed CEO

Feb 2022

Established CuroV Science, Inc. in Ottawa, Canada

2021

RC402-IT Australia Phase 1 clinical trial (1a/1b) in progress

July 2020
Strategic R&D co-op. agreement  with CHA Bundang Medical Center & strategic partnership with Y Biologics
October 2019
Established ViroCure Australia in Brisbane

April 2019
Investment & strategic partnership with EDGC
 
December 2017
Strategic co-op. agreement with Seoul Asan Hospital
 
September 2017
Opened ViroCure USA lab at Moffit Cancer Center

June 2016
Established ViroCure, Inc.
2013
Established Cancer Virus Research Center at Dankook University College of Medicine for OV research
1999
Foundational research on oncolytic virology at the University of Calgary

Leadership Team

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Prof. Dong Guk Park, CEO

Dankook Univ. Med School, Director of Cancer Center, Chief Surgeon, Dean of Graduate Medical School
Univ. of Calgary, Visiting Professor
Seoul National Univ. Med School MD, Ph.D

 

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Yeon Sook Lee, CTO

Medical Bioconvergence Research Center

Director/VP, SillaJen

CTO, Nyujenpam

Korea University PhD

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Prof. Nam Hyuk Cho, CSO

Professor, SNU Medical School
Harvard Medical School, Post-doc

SNU Medical School, PhD

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Prof. Tommy Alain, CSO North America

CEO, CuroV Science, Inc.

University of Ottawa

CHEO Research Institute

Microbiology & Immunology

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Haeng Jun Yoo, Executive Advisor

CEO, Amicogen, Inc.

President, Jeonbuk Institute for Bioindustry

CEO, CJ Cheiljedang Bio Business Unit 

Samsung Group Chairman's Office

Seoul National University 

Scientific Advisory Board

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Prof. Chungsoo Kim

ASAN Medical Center

Prostrate Cancer

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Prof. Minhee Ryu

ASAN Medical Center

Medical Oncology

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Prof. Woochan Son

ASAN Medical Center

Pathology

Veterinary Science

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Prof. Hongjae Jeon

Bundang CHA Hospital

Director, Cancer Center

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Prof. Chan Kim

Bundang CHA Hospital

Colorectal, Urinary, Sarcoma