What we do

Naturally occurring viruses are live replication-proficient viruses specifically infecting human cancer cells while sparing their normal counterparts.

 

Since the discovery of naturally oncotropic viruses in the 1920s, various replicating viruses have shown degrees of safety and efficacy in pre-clinical and clinical application for human anti-cancer therapeutics. Cellular oncogenes such as Ras and c-Myc are known to be important host genes for oncolytic viral tropism decision.

 

Importantly, we recently discovered that cellular tumor suppressor genes are also important in determining oncolytic viral tropism. Carcinogenesis is a multi-step process involving accumulation of not only oncogene abnormality but also the accumulation of tumor suppressor gene abnormality. Thus, it is interesting that oncolytic viruses are known to exploit abnormal oncogene and cellular tumor suppressor signaling, frequently dysregulated in various human malignancies, for their decision of oncolytic specificity and efficacy.

 

Unlike oncogenes, many tumor suppressor genes such as p53, ATM, and RB are known to play important roles in genomic fidelity & maintenance. Thus tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to accumulation of genetic defects resulting in natural viral oncotropism.

 

ViroCure finds naturally occurring oncotropic viruses for targeting various human or animal malignancies, to develop safe and effective treatments to a wide variety of illnesses.

Highlights

2021

RC402-IT Australia Phase 1 clinical trial (1a/1b) in progress

July 2020
Strategic R&D co-op. agreement  with CHA Bundang Medical Center & strategic partnership with Y Biologics
October 2019
Established ViroCure Australia in Brisbane

April 2019
Investment & strategic partnership with EDGC
 
December 2017
Strategic co-op. agreement with Seoul Asan Hospital
 
September 2017
Opened ViroCure USA lab at Moffit Cancer Center

June 2016
Established ViroCure, Inc.
2013
Established Cancer Virus Research Center at Dankook University College of Medicine for OV research
1999
Foundational research on oncolytic virology at the University of Calgary

Leadership Team

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Haeng Jun Yoo, CEO

CEO, Amicogen, Inc.

President, Jeonbuk Institute for Bioindustry

CEO, CJ Cheiljedang Bio Business Unit 

Samsung Group Chairman's Office

Seoul National University 

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Yeon-Sook Lee, CTO

(주)온코태그디아그노스틱 대표이사
(재)의약바이오컨버전스연구단 기술사업화팀장
신라젠(주) 연구소장/부사장
(주)뉴젠팜 연구소장
고려대학교 학사/석사/박사

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Prof. Tommy Alain, CSO

University of Ottawa

CHEO Research Institute

Microbiology & Immunology

Scientific Advisory Board

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Prof. Chungsoo Kim

ASAN Medical Center

Prostrate Cancer

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Prof. Hongjae Jeon

Bundang CHA Hospital

Director, Cancer Center

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Prof. Minhee Ryu

ASAN Medical Center

Medical Oncology

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Prof. Chan Kim

Bundang CHA Hospital

Colorectal, Urinary, Sarcoma

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Prof. Woochan Son

ASAN Medical Center

Pathology

Veterinary Science

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Prof. Randal Johnston

University of Calgary